One of the longest words in the english language without the letter E is Floccinaucinihilipilification. It means the act of declaring something worthless.

The word was derived from a grammar book that listed four different Latin words that all roughly meant "of little or no value" (floccus, pilus, nihil, and nauci). There were strung together with "-fication" into one word as a joke. Fittingly, we now have an unnecessarily long, pointless word that describes the act of deciding that something is totally and absolutely valueless.
Think you can use it in a sentence? Its first recorded use was in 1741 by poet William Shenstone:
“I loved him for nothing so much as his flocci-nauci-nihili-pili-fication of money.”
More recently it was used by the late Senator Jesse Helms in 1999:
“I note your distress at my floccinaucinihilipilification of the CTBT [Comprehensive Test Ban Treaty”.